Signal Switching, Crosstalk, and Arrestin Scaffolds

Activation and targeting of extracellular signal-regulated kinases by beta-arrestin scaffolds.

Using both confocal immunofluorescence microscopy and biochemical approaches, we have examined the role of beta-arrestins in the activation and targeting of extracellular signal-regulated kinase 2 (ERK2) following stimulation of angiotensin II type 1a receptors (AT1aR). In HEK-293 cells expressing hemagglutinin-tagged AT1aR, angiotensin stimulation triggered beta-arrestin-2 binding to the recep...

Subterahertz signal crosstalk in transmission line interconnects

A low-temperature electro-optic sampling system was implemented to study the crosstalk of picosecond pulses between on-chip microstrip interconnects. With a submillivolt sensitivity and a subpicosecond temporal response, this system has allowed noninvasive, nodal testing of superconducting Nb integrated circuits. We have characterized pulse propagation and the crosstalk arising from two microst...

Photonic Rearrangeable Networks with Zero Switching-Element Crosstalk

Arrestin orchestrates crosstalk between G protein-coupled receptors to modulate the spatiotemporal activation of ERK MAPK.

RATIONALE G protein-coupled receptors (GPCRs) respond to diversified extracellular stimuli to modulate cellular function. Despite extensive studies investigating the regulation of single GPCR signaling cascades, the effects of concomitant GPCR activation on downstream signaling and cellular function remain unclear. OBJECTIVE We aimed to characterize the cellular mechanism by which GPCR crosst...

Pathogen-Induced Defense Signaling and Signal Crosstalk in Arabidopsis

............................................................................................................................................. 8 INTRODUCTION.................................................................................................................................... 9 PLANT-PATHOGEN INTERACTION ..................................................................................